Chinese Medicine Regulatory Office

Analysis of chemical markers of Chinese Materia Medica in proprietary Chinese medicines for internal use (Pei Pa Koa)

This research project aims at developing and validating testing methods for the determination of chemical markers of Chinese materia medica (CMM) commonly found in Pei Pa Koa. This project is divided into two phases. In the first phase, a test method for qualitative and quantitative analysis of chemical markers in Bulbus fritillariae cirrhosae, Platycodon grandiflorum and Armeniacae Semen Amarum will be developed and validated. In the second phase, test methods for the qualitative and quantitative analysis of chemical markers in menthol, Eriobotryae Folium, Glycyrrhizae Radix Et Rhizoma and Citri Grandis Exocarpium will be developed and validated.


  • Validated multi-analytes testing methods;
  • Convenient, simple, easy and common testing methods;
  • Use of advanced instrumentation for the analysis of chemical markers at less than 0.1 ppm level.

The aim of this project is to provide analytical method(s) for Chinese Medicines traders and testing sectors as reference. They can adopt the multi-analytes testing methods as the quality control method. This would help to reduce the investment on method development and validation. In addition, through analyzing more chemical markers of the characteristic CMM and adopting a product-specific quality standard, the CM industry could strengthen the quality control of the pCm products. This would help to establish the brand image of Hong Kong in Chinese medicines.

Testing Methods

*This project intends to provide reliable analytical methods that could be used as quality control methods for determining the targeted chemical marker(s) of CMMs in the Pei Pa Koa products. When using these methods, it is the user's responsibility to assess whether these test methods are applicable to their products.